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well if you consider principles of photography the higher the fstop number the less depth of field you get so you can keep stuff in focus further away. so as if you shot at f/2.8 your in focus plane will be very thin, easily able to take a step in or out of focus. however if you shot at say f/16, your subject could take several steps and still remain in that sweet spot. it might not be RAZOR sharp but it'll be in focus.
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